解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:STUDY OBJECTIVE:To evaluate the effect of acarbose on glycemic control and glycemic variability, using a continuous glucose-monitoring system, in patients with type 2 diabetes mellitus who were not well controlled on metformin and vildagliptin therapy. DESIGN:Multicenter, randomized, double-blind, placebo-controlled s...
journal_title:Pharmacotherapy
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1002/phar.1648
更新日期:2015-11-01 00:00:00
abstract::Our objective was to describe the implementation and clinical outcomes of an employer-sponsored, pharmacist-provided medication therapy management (MTM) program for health plan beneficiaries with diabetes mellitus and/or hypertension. We conducted a single-center retrospective medical record review. The setting was a ...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1002/phar.1650
更新日期:2015-11-01 00:00:00
abstract::Health care-associated infections, especially those caused by multidrug-resistant gram-positive organisms, such as methicillin-resistant Staphylococcus aureus (MRSA), are a growing public health threat. In 2014, the U.S. Food and Drug Administration approved two new lipoglycopeptides, oritavancin and dalbavancin, for ...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1002/phar.1641
更新日期:2015-10-01 00:00:00
abstract::Use of the Molecular Adsorbent Recirculating System (MARS) as a liver support device continues to grow worldwide. Various components of the MARS circuit remove both protein-bound and water-soluble molecules. Little is known about the extent of the enhanced clearance mechanisms used in MARS therapy on drug elimination....
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1002/phar.1618
更新日期:2015-08-01 00:00:00
abstract::Apixaban, a direct factor Xa inhibitor, is a novel oral anticoagulant (NOAC) indicated for prevention of embolic events in patients with nonvalvular atrial fibrillation. The agent is associated with a lower risk of bleeding compared with vitamin K antagonists such as warfarin. Hemopericardium is a life-threatening ble...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1002/phar.1602
更新日期:2015-07-01 00:00:00
abstract:OBJECTIVE:To evaluate the safety and efficacy of alfuzosin treatment on rate and time of stone expulsion in patients with uncomplicated distal ureteral stones. PATIENTS AND METHODS:Prospective, randomized, open-label, controlled study. Patients > 18 years of age presenting to the outpatient urology clinic with uncompl...
journal_title:Pharmacotherapy
pub_type: 杂志文章,随机对照试验
doi:10.1002/phar.1593
更新日期:2015-05-01 00:00:00
abstract::Staphylococcus aureus (S. aureus) has proven to be a major pathogen with the emergence of methicillin-resistant S. aureus (MRSA) infections and recently with heteroresistant vancomycin-intermediate S. aureus (hVISA) and vancomycin-intermediate S. aureus (VISA) infections. Although vancomycin is traditionally a first-l...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1002/phar.1577
更新日期:2015-04-01 00:00:00
abstract::Triclosan is a synthetic biocide found in many household products, including antimicrobial hand soap. Levels of triclosan have been found throughout the environment and in human urine, blood, and even breast milk. Increasing levels of exposure to triclosan have led to concerns over the development of resistance to tri...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1002/phar.1553
更新日期:2015-03-01 00:00:00
abstract::Warfarin, a vitamin K antagonist, has been the only orally available anticoagulant for > 60 years. During the past decade, the U.S. Food and Drug Administration has approved several target-specific oral anticoagulants (TSOACs) for the prophylaxis and treatment of arterial and venous thromboembolism and stroke preventi...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1002/phar.1532
更新日期:2015-02-01 00:00:00
abstract::Disseminated herpes simplex virus (HSV) infection in neonates represents a devastating entity that yields high mortality. Acyclovir is the primary antiviral agent used to treat life-threatening HSV infections in neonates; however, even though the agent has reduced morbidity overall from these infections, mortality wit...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1002/phar.1526
更新日期:2015-02-01 00:00:00
abstract::Colistin, the most widely used polymyxin antibiotic, was originally introduced in the late 1950s before the establishment of the present-day drug approval process. Originally shelved due to toxicity concerns, colistin, in the form of its inactive prodrug colistin methanesulfonate, has undergone a renaissance in the pa...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1002/phar.1484
更新日期:2015-01-01 00:00:00
abstract::The systemic polymyxins, colistin and polymyxin B, are increasingly used for multidrug-resistant bacterial infections and have a long history of dose-limiting toxicity. This review summarizes the most recent available information about the mechanisms, incidence, risk factors, and minimization strategies for polymyxin ...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1002/phar.1493
更新日期:2015-01-01 00:00:00
abstract::Antimicrobial susceptibility testing for the polymyxins-colistin and polymyxin B-is fraught with technical challenges. Key among these is the propensity of the polymyxins to adsorb to polystyrene, a material often used for in vitro minimum inhibitory concentration testing devices. This effect may be mitigated by the a...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1002/phar.1505
更新日期:2015-01-01 00:00:00
abstract::A hiccup is a myoclonic jerk of the diaphragm, and cases of hiccups may last for more than 48 hours (persistent hiccups) or even more than 2 months (intractable hiccups). Current pharmacologic treatment of persistent or intractable hiccups mainly includes antidopaminergic drugs. We describe the case of a 60-year-old m...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1002/phar.1523
更新日期:2014-12-01 00:00:00
abstract:STUDY OBJECTIVE:To review quantitatively and qualitatively the U.S. Food and Drug Administration (FDA) Adverse Event Reporting System (AERS) database to provide clinicians with a general understanding of the comparative occurrence of clinically meaningful adverse events associated with 15 antimicrobial new molecular en...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1002/phar.1519
更新日期:2014-12-01 00:00:00
abstract::Antimicrobial resistance among gram-positive organisms such as methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE) continues to limit therapeutic options. The oxazolidinones are a synthetic class of agents now commonly relied on for the treatment of serious MRSA and VRE infect...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1002/phar.1491
更新日期:2014-11-01 00:00:00
abstract:STUDY OBJECTIVE:To assess the reproducibility of Naranjo Adverse Drug Reaction Probability Scale (APS) scores in published case reports. DESIGN:Reliability analysis. MEASUREMENTS AND MAIN RESULTS:Randomly selected case reports using the APS were identified from the Web of Science database. The APS scores were blinded...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1002/phar.1496
更新日期:2014-11-01 00:00:00
abstract::Widespread anecdotal use of sublingual tacrolimus administration has arisen, although little literature exists to guide practice. Given the paucity of data, we conducted a survey to evaluate the practice of sublingual tacrolimus administration at transplant centers across the United States and evaluated the literature...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1002/phar.1492
更新日期:2014-11-01 00:00:00
abstract::Bedaquiline is a diarylquinoline antitubercular drug with a novel mechanism of action against Mycobacterium tuberculosis. Bedaquiline works by inhibiting bacterial adenosine triphosphate (ATP) synthase and represents the first novel class of antituberculosis agents in more than 40 years. Bedaquiline is indicated for t...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1002/phar.1482
更新日期:2014-11-01 00:00:00
abstract::Postoperative atrial fibrillation (POAF) is the most common complication following cardiac surgery, occurring in up to 65% of cardiac surgical patients. It is a condition associated with increased morbidity, increased length of hospital stay, and increased health care costs. One of the many potential causes of POAF is...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1002/phar.1485
更新日期:2014-11-01 00:00:00
abstract::Pharmacists are uniquely qualified to play essential roles in the clinical implementation of pharmacogenomics. However, specific responsibilities and resources needed for these roles have not been defined. We describe roles for pharmacists that emerged in the clinical implementation of genotype-guided clopidogrel ther...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1002/phar.1481
更新日期:2014-10-01 00:00:00
abstract:OBJECTIVE:To determine if asthma control improves in patients who receive physician-pharmacist collaborative management (PPCM) during visits to primary care medical offices. DESIGN:Prospective pre-post study of patients who received the intervention in primary care offices for 9 months. The primary outcome was the sum...
journal_title:Pharmacotherapy
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1002/phar.1468
更新日期:2014-10-01 00:00:00
abstract:OBJECTIVE:To describe the legal, professional, and consumer status of prescribers dispensing legend and over-the-counter drugs in the United States. METHODS:Legal and academic databases were searched to identify those states that permit prescribers to dispense medications to patients and any limitations on such practi...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1002/phar.1461
更新日期:2014-10-01 00:00:00
abstract::The U.S. population continues to experience an alarmingly high rate of unintended pregnancies that have an impact on individual families and society alike. Lack of effective contraception accounts for most unintended pregnancies, along with incorrect use of contraceptives. The most common reversible contraceptive meth...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1002/phar.1457
更新日期:2014-09-01 00:00:00
abstract:STUDY OBJECTIVE:Evaluate dabigatran adverse event reports with a reported bleeding event and/or reported fatal outcome compared with warfarin. DESIGN:Retrospective analysis of the FDA Adverse Event Reporting System (FAERS) database. MEASUREMENTS AND MAIN RESULTS:We identified reports from October 1, 2010, through Dec...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1002/phar.1415
更新日期:2014-06-01 00:00:00
abstract::Multiple myeloma is the second most common type of hematologic malignancy. It is a B-cell malignancy that affects the bone marrow and often results in thrombocytopenia as well as renal dysfunction. Treatment options range from oral and intravenous chemotherapy to bone marrow transplantation and supportive care. Carfil...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1002/phar.1397
更新日期:2014-05-01 00:00:00
abstract::Lymphoid malignancies comprise a heterogeneous group of disorders originating from clonal proliferation of B or T lymphocytes. Treatment of lymphoid neoplasms has traditionally been pursued with cytotoxic chemotherapy. To improve efficacy and ameliorate the adverse effects associated with classic chemotherapy, molecul...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1002/phar.1366
更新日期:2014-03-01 00:00:00
abstract:STUDY OBJECTIVE:To assess the relationship of the 33 single nucleotide polymorphisms (SNPs) previously associated with fasting glucose in Caucasians in genome-wide association studies (GWAS) with glucose response to antihypertensive drugs shown to increase risk for hyperglycemia and diabetes. DESIGN:Randomized, multic...
journal_title:Pharmacotherapy
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1002/phar.1355
更新日期:2014-02-01 00:00:00
abstract:STUDY OBJECTIVE:To evaluate the effects of topical atorvastatin on the healing process of pressure ulcers in critically ill patients. DESIGN:Randomized, double-blind, placebo-controlled clinical trial. SETTING:Medical-surgical intensive care unit of a university-affiliated teaching hospital in Tehran, Iran. PATIENTS...
journal_title:Pharmacotherapy
pub_type: 杂志文章,随机对照试验
doi:10.1002/phar.1339
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVES:To compare the usage and cost of antibiotics in the United States and United Kingdom in children younger than 10 years. METHODS:A follow up of some 160,000 young children enrolled in U.S. private health insurance companies and an equal number in general practices in the United Kingdom in 2009, based on two ...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1002/phar.1387
更新日期:2014-01-01 00:00:00
abstract::Developing clinical pharmacists' research skills and their ability to compete for extramural funding is an important component of the American College of Clinical Pharmacy's (ACCP) vision for pharmacists to play a prominent role in generating the new knowledge used to guide patient pharmacotherapy. Given the recent em...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1002/phar.1348
更新日期:2013-12-01 00:00:00
abstract::With the emergence of new anticoagulants, clinicians need a thorough understanding of coagulation assays. Various laboratory assays exist to measure the effectiveness of anticoagulants. Coagulation assays are the primary method for measuring the effectiveness of anticoagulants; therefore, a comprehensive understanding...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1002/phar.1283
更新日期:2013-11-01 00:00:00
abstract:STUDY OBJECTIVE:To assess patients' perception of care delivery by anticoagulation clinics (ACs) throughout Alberta, Canada. DESIGN:Prospective postal survey. SETTING:Therapy provision by an AC to ambulatory-based patients for a minimum of 3 months across the province. PATIENTS:A total of 1687 patients (67.9%) recei...
journal_title:Pharmacotherapy
pub_type: 杂志文章,多中心研究
doi:10.1002/phar.1318
更新日期:2013-11-01 00:00:00
abstract:STUDY OBJECTIVE:To determine if development of acneiform rash is a predictor of objective response rate with lapatinib. DESIGN:Subanalysis of data from a prospective, phase II study. SETTING:Academic breast care clinic. PATIENTS:Forty-nine treatment-naïve patients with human epidermal growth factor receptor-2 (HER2)...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1002/phar.1308
更新日期:2013-10-01 00:00:00
abstract::In patients infected with chronic hepatitis B virus (HBV) that goes untreated, therapeutic options are limited once the disease decompensates, and orthotopic liver transplantation is often the only treatment available to save the patient's life. After liver transplantation, combined therapy with hepatitis B immune glo...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1002/phar.1306
更新日期:2013-09-01 00:00:00
abstract:STUDY OBJECTIVE:To categorize institutional review board (IRB) challenges and solutions encountered in a multicenter practice-based research network (PBRN) study and to assess the impact of IRB requirements on the willingness of individual principal investigators (PIs) to participate in future PBRN studies. DESIGN:Des...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1002/phar.1276
更新日期:2013-09-01 00:00:00
abstract::We present a case of eosinophilic pneumonia due to ceftaroline used for the treatment of methicillin-resistant Staphylococcus aureus bacteremia associated with a postoperative spinal infection. Our patient developed shortness of breath and hypoxemia on the fifth week of ceftaroline therapy. Chest imaging disclosed dif...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1002/phar.1286
更新日期:2013-07-01 00:00:00
abstract::Ischemic stroke is a prevalent disease with a large burden on the health system. Preventive strategies, therefore, are paramount. Primary prevention is aimed at reducing the risk of stroke in asymptomatic people. The most effective prevention is through control of modifiable risk factors. Due to the large amount of li...
journal_title:Pharmacotherapy
pub_type:
doi:10.1002/phar.1255
更新日期:2013-06-01 00:00:00
abstract::Hypoactive sexual desire disorder (HSDD) affects nearly 1 in 10 women. Thus, it is essential for pharmacists and other health care providers to be comfortable when discussing a patient's sexual health to ensure appropriate triage so that the specific causes of HSDD can be identified and potential recommendations provi...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1002/phar.1209
更新日期:2013-04-01 00:00:00
abstract::Two drugs commonly used in triple-drug therapy for treatment of a Helicobacter pylori infection, clarithromycin and omeprazole, have rarely been associated with hypoglycemia when given alone. No documented interactions between H. pylori treatment with clarithromycin, amoxicillin, and omeprazole and insulin detemir hav...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1002/phar.1228
更新日期:2013-04-01 00:00:00